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1

Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors

Belema, Makonen, Lopez, Omar D., Bender, John A., Romine, Jeffrey L., St. Laurent, Denis R., Langley, David R., Lemm, Julie A., O’Boyle, Donald R., Sun, Jin-Hua, Wang, Chunfu, Fridell, Robert A., Mean

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.08 MB

english, 2014

2

Synthesis of Aminoboronic Acid Derivatives from Amines and Amphoteric Boryl Carbonyl Compounds

Diaz, Diego B., Scully, Conor C. G., Liew, Sean K., Adachi, Shinya, Trinchera, Piera, St. Denis, Jeffrey D., Yudin, Andrei K.

Journal:

Angewandte Chemie

Year:

2016

Language:

english

File:

PDF, 810 KB

english, 2016

3

Amphoteric α-Boryl Aldehyde Linchpins in the Synthesis of Heterocycles

St. Denis, Jeffrey D., He, Zhi, Yudin, Andrei K.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.17 MB

english, 2015

4

Direct Intramolecular Catalytic Enantioselective Alkylation of Oxazolidinone Bromoalkanoate Imides

De Rycke, Nicolas, St Denis, Jeffrey, Hughes, Jonathan, Rosadiuk, Kristopher, Gleason, James

Journal:

Year:

2014

Language:

english

File:

PDF, 231 KB

english, 2014

5

Boron-Containing Enamine and Enamide Linchpins in the Synthesis of Nitrogen Heterocycles

St. Denis, Jeffrey D., Zajdlik, Adam, Tan, Joanne, Trinchera, Piera, Lee, C. Frank, He, Zhi, Adachi, Shinya, Yudin, Andrei K.

Journal:

Journal of the American Chemical Society

Year:

2014

Language:

english

File:

PDF, 1.17 MB

english, 2014

6

Oxidative Geminal Functionalization of Organoboron Compounds

He, Zhi, Trinchera, Piera, Adachi, Shinya, St. Denis, Jeffrey D., Yudin, Andrei K.

Journal:

Angewandte Chemie

Year:

2012

Language:

english

File:

PDF, 417 KB

english, 2012

7

Condensation-Driven Assembly of Boron-Containing Bis(Heteroaryl) Motifs Using a Linchpin Approach

Adachi, Shinya, Liew, Sean K., Lee, C. Frank, Lough, Alan, He, Zhi, Denis, Jeffrey D. St., Poda, Gennady, Yudin, Andrei K.

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 864 KB

english, 2015

8

Activation of Alkynylzinc Reagents by a Hemiaminal-Driven Catalytic Microenvironment

St. Denis, Jeffrey D., Liew, Sean K., Scully, Conor C. G., Yudin, Andrei K.

Journal:

European Journal of Organic Chemistry

Year:

2017

Language:

english

File:

PDF, 1.44 MB

english, 2017

9

ChemInform Abstract: Amphoteric α-Boryl Aldehyde Linchpins in the Synthesis of Heterocycles

St. Denis, Jeffrey D., He, Zhi, Yudin, Andrei K.

Journal:

Year:

2015

File:

PDF, 80 KB

2015

10

Chemoselective palladium-catalyzed α-allylation of α-boryl aldehydes

St. Denis, Jeffrey D., He, Zhi, Yudin, Andrei K.

Journal:

Organic & Biomolecular Chemistry

Year:

2012

Language:

english

File:

PDF, 246 KB

english, 2012

11

Stereocontrolled Disruption of the Ugi Reaction toward the Production of Chiral Piperazinones: Substrate Scope and Process Development

Zaretsky, Serge, Adachi, Shinya, Rotstein, Benjamin H., Hickey, Jennifer L., Scully, Conor C. G., St. Denis, Jeffrey D., Courtemanche, Rebecca, Yu, Joy C. Y., Chung, Benjamin K. W., Yudin, Andrei K.

Journal:

Journal of Organic Chemistry

Year:

2014

Language:

english

File:

PDF, 560 KB

english, 2014

12

Evaluation of a chiral cubane-based Schiff base ligand in asymmetric catalysis reactions

Biegasiewicz, Kyle F, Ingalsbe, Michelle L, St. Denis, Jeffrey D, Gleason, James L, Ho, Junming, Coote, Michelle L, Savage, G Paul, Priefer, Ronny

Journal:

Beilstein Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 790 KB

english, 2012

13

Synthesis of a Novel Chiral Cubane-Based Schiff Base Ligand and Its Application in Asymmetric Nitro-Aldol (Henry) Reactions

Ingalsbe, Michelle, St. Denis, Jeffrey, Gleason, James, Savage, G., Priefer, Ronny

Journal:

Year:

2010

Language:

english

File:

PDF, 99 KB

english, 2010

14

Low-dose methotrexate with leucovorin (folinic acid) in the management of rheumatoid arthritis. results of a multicenter randomized, double-blind, placebo-controlled trial

Jeffrey B. Shiroky, Carolyn Neville, John M. Esdaile, Denis Choquette, Michel Zummer, Mark Hazeltine, Vivian Bykerk, Mohamed Kanji, Anne St-Pierre, Lise Robidoux, Lucienne Bourque

Journal:

Arthritis & Rheumatism

Year:

1993

Language:

english

File:

PDF, 907 KB

english, 1993

15

Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons

Belema, Makonen, Nguyen, Van N., Romine, Jeffrey L., St. Laurent, Denis R., Lopez, Omar D., Goodrich, Jason T., Nower, Peter T., O’Boyle, Donald R., Lemm, Julie A., Fridell, Robert A., Gao, Min, Fang,

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 931 KB

english, 2014

16

ChemInform Abstract: Development of the Direct Suzuki-Miyaura Cross-Coupling of Primary B-Alkyl MIDA-Boronates and Aryl Bromides.

St. Denis, Jeffrey D., Scully, Conor C. G., Lee, C. Frank, Yudin, Andrei K.

Journal:

Year:

2014

File:

PDF, 22 KB

2014

17

Development of a novel expression, ZIMAX/KZI, for determination of the counter-anion effect on the antimicrobial activity of tetrabutylammonium salts

Michelle L. Ingalsbe, Jeffrey D.St. Denis, Megan E. McGahan, Walter W. Steiner, Ronny Priefer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 267 KB

english, 2009

18

Oxidative Geminal Functionalization of Organoboron Compounds

He, Zhi, Trinchera, Piera, Adachi, Shinya, St. Denis, Jeffrey D., Yudin, Andrei K.

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 424 KB

english, 2012

19

Access to Cyclic Amino Boronates via Rhodium-Catalyzed Functionalization of Alkyl MIDA Boronates

St. Denis, Jeffrey D., Lee, C. Frank, Yudin, Andrei K.

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 750 KB

english, 2015

20

ChemInform Abstract: Stereocontrolled Synthesis of 1,2- and 1,3-Diamine Building Blocks from Aziridine Aldehyde Dimers.

Liew, Sean K., He, Zhi, St. Denis, Jeffrey D., Yudin, Andrei K.

Journal:

Year:

2014

File:

PDF, 27 KB

2014

21

ChemInform Abstract: Condensation-Driven Assembly of Boron-Containing Bis(Heteroaryl) Motifs Using a Linchpin Approach.

Adachi, Shinya, Liew, Sean K., Lee, C. Frank, Lough, Alan, He, Zhi, Denis, Jeffrey D. St., Poda, Gennady, Yudin, Andrei K.

Journal:

Year:

2016

File:

PDF, 28 KB

2016

22

ChemInform Abstract: Access to Cyclic Amino Boronates via Rhodium-Catalyzed Functionalization of Alkyl MIDA Boronates.

St. Denis, Jeffrey D., Lee, C. Frank, Yudin, Andrei K.

Journal:

Year:

2016

File:

PDF, 30 KB

2016

23

Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles

Lee, C. Frank, Holownia, Aleksandra, Bennett, James M., Elkins, Jonathan M., St. Denis, Jeffrey D., Adachi, Shinya, Yudin, Andrei K.

Journal:

Angewandte Chemie International Edition

Year:

2017

Language:

english

File:

PDF, 1.08 MB

english, 2017

24

Development of the Direct Suzuki–Miyaura Cross-Coupling of Primary B -Alkyl MIDA-boronates and Aryl Bromides

St. Denis, Jeffrey D., Scully, Conor C. G., Lee, C. Frank, Yudin, Andrei K.

Journal:

Organic Letters

Year:

2014

Language:

english

File:

PDF, 410 KB

english, 2014

25

Characterizations of HCV NS5A replication complex inhibitors

O'Boyle II, Donald R., Sun, Jin-Hua, Nower, Peter T., Lemm, Julie A., Fridell, Robert A., Wang, Chunfu, Romine, Jeffrey L., Belema, Makonen, Nguyen, Van N., Laurent, Denis R. St., Serrano-Wu, Michael,

Journal:

Year:

2013

Language:

english

File:

PDF, 2.18 MB

english, 2013

26

Efficient Preparation of α-Aminoboronic Acid Derivatives via Boroalkyl Group Migration

Zajdlik, Adam, He, Zhi, St Denis, Jeffrey, Yudin, Andrei

Journal:

Year:

2014

Language:

english

File:

PDF, 268 KB

english, 2014

27

ChemInform Abstract: Direct Intramolecular Catalytic Enantioselective Alkylation of Oxazolidinone Bromoalkanoate Imides.

De Rycke, Nicolas, St Denis, Jeffrey D., Hughes, Jonathan M. E., Rosadiuk, Kristopher A., Gleason, James L.

Journal:

Year:

2015

File:

PDF, 17 KB

2015

28

ChemInform Abstract: Novel Synthesis of the Isoflavone Genistein.

Jeffrey D. St. Denis, James S. IV Gordon, Vincent M. Carroll, Ronny Priefer

Journal:

Year:

2010

File:

PDF, 31 KB

2010

29

Boroalkyl Group Migration Provides a Versatile Entry into α-Aminoboronic Acid Derivatives

He, Zhi, Zajdlik, Adam, St. Denis, Jeffrey D., Assem, Naila, Yudin, Andrei K.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 474 KB

english, 2012

30

Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d -glucopyranosyl]-5 H ,13 H -benzo[ b ]- thienyl[2,3- a ]pyrrolo[3,4- c ]carbazole- 5,7(6 H )-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model §

Balasubramanian, Balu N., St. Laurent, Denis R., Saulnier, Mark G., Long, Byron H., Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R., Frennesso

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 96 KB

english, 2004

31

Stereocontrolled Synthesis of 1,2- and 1,3-Diamine Building Blocks from Aziridine Aldehyde Dimers

Liew, Sean K., He, Zhi, St. Denis, Jeffrey D., Yudin, Andrei K.

Journal:

Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 1003 KB

english, 2013

32

An efficient synthesis of daidzein, dimethyldaidzein, and isoformononetin

Kyle F. Biegasiewicz, Jeffrey D. St. Denis, Vincent M. Carroll, Ronny Priefer

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 298 KB

english, 2010

33

Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d -glucopyranosyl]-5 H ,13 H -benzo[ b ]thienyl[2,3- a ]pyrrolo[3,4- c ]carbazole-5,7(6 H )-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model.

Balasubramanian, Balu N., St. Laurent, Denis R., Saulnier, Mark G., Long, Byron H., Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R., Frennesso

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 28 KB

english, 2005

34

Concepts and Principles of Photodynamic Therapy as an Alternative Antifungal Discovery Platform

Dai, Tianhong, Fuchs, Beth B., Coleman, Jeffrey J., Prates, Renato A., Astrakas, Christos, St. Denis, Tyler G., Ribeiro, Martha S., Mylonakis, Eleftherios, Hamblin, Michael R., Tegos, George P.

Journal:

Frontiers in Microbiology

Year:

2012

Language:

english

File:

PDF, 1.88 MB

english, 2012

35

Discovery of a Fluoroindolo[2,3- a ]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11 †

Saulnier, Mark G., Balasubramanian, Balu N., Long, Byron H., Frennesson, David B., Ruediger, Edward, Zimmermann, Kurt, Eummer, Jeffrey T., St. Laurent, Denis R., Stoffan, Karen M., Naidu, B. Narasimhu

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 136 KB

english, 2005

36

ChemInform Abstract: Boron-Containing Enamine and Enamide Linchpins in the Synthesis of Nitrogen Heterocycles.

St. Denis, Jeffrey D., Zajdlik, Adam, Tan, Joanne, Trinchera, Piera, Lee, C. Frank, He, Zhi, Adachi, Shinya, Yudin, Andrei K.

Journal:

Year:

2015

File:

PDF, 24 KB

2015

37

Synthesis of Aminoboronic Acid Derivatives from Amines and Amphoteric Boryl Carbonyl Compounds

Diaz, Diego B., Scully, Conor C. G., Liew, Sean K., Adachi, Shinya, Trinchera, Piera, St. Denis, Jeffrey D., Yudin, Andrei K.

Journal:

Angewandte Chemie International Edition

Year:

2016

Language:

english

File:

PDF, 882 KB

english, 2016

38

The NSSI Paradox: Discussing and Displaying NSSI in an Online Environment

Rodham, Karen, Gavin, Jeffrey, Lewis, Stephen, Bandalli, Peter, St. Denis, Jill

Journal:

Deviant Behavior

Year:

2016

Language:

english

File:

PDF, 791 KB

english, 2016

39

ChemInform Abstract: Preparation of 5-Substituted 2-(2-Alkyl/Aryl-1H-imidazol-4-yl)oxazoles and 5-Substituted 2-(2-Alkyl/Arylthiazol-4-yl)oxazoles by Utilizing 5-Substituted 2-(2-Bromo-1,1-diethoxyethyl)oxazole as a Synthon.

Denis R. St. Laurent, Jeffrey L. Romine

Journal:

Year:

2009

File:

PDF, 38 KB

2009

40

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes

Romine, Jeffrey L., St. Laurent, Denis R., Leet, John E., Martin, Scott W., Serrano-Wu, Michael H., Yang, Fukang, Gao, Min, O’Boyle, Donald R, Lemm, Julie A., Sun, Jin-Hua, Nower, Peter T., Huang, Xia

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

41

Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles

Lee, C. Frank, Holownia, Aleksandra, Bennett, James M., Elkins, Jonathan M., St. Denis, Jeffrey D., Adachi, Shinya, Yudin, Andrei K.

Journal:

Angewandte Chemie

Year:

2017

Language:

english

File:

PDF, 1.02 MB

english, 2017

42

Facile synthesis of borofragments and their evaluation in activity-based protein profiling

Adachi, Shinya, Cognetta, Armand B., Niphakis, Micah J., He, Zhi, Zajdlik, Adam, St. Denis, Jeffrey D., Scully, Conor C. G., Cravatt, Benjamin F., Yudin, Andrei K.

Journal:

Chemical Communications

Year:

2015

Language:

english

File:

PDF, 1.59 MB

english, 2015

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